Gefen Lab
PUBLICATIONS
See our most recent publications
NEUROPATHOLOGICAL FINGERPRINTS OF SURVIVAL, ATROPHY AND LANGUAGE IN PRIMARY PROGRESSIVE APHASIA
Mesulam MM, Coventry CA, Bigio EH, Sridhar J, Gill N, Fought AJ, Zhang H, Thompson CK, Geula C, Gefen T*, Flanagan M, Mao Q, Weintraub S, Rogalski EJ. Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia. Brain. 2022 Apr 20:awab410. doi: 10.1093/brain/awab410. Epub ahead of print. PMID: 35441216.
CORTICAL AND SUBCORTICAL PATHOLOGICAL BURDEN AND NEURONAL LOSS IN AN AUTOPSY SERIES OF FTLD-TDP-TYPE C
Kawles A*, Nishihira Y, Feldman A, Gill N, Minogue G*, Keszycki R*, Coventry C, Spencer C, Lilek J, Ajroud K, Coppola G, Rademakers R, Rogalski E, Weintraub S, Zhang H, Flanagan ME, Bigio EH, Mesulam MM, Geula C, Mao Q, Gefen T*. Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C. Brain. 2021 Dec 17:awab368. doi: 10.1093/brain/awab368. Epub ahead of print. PMID: 34919645.
PROPAGATION OF TDP-43 PROTEINOPATHY IN NEURODEGENERATIVE DISORDERS
Keszycki R*, Jamshidi P, Kawles A*, Minogue G*, Flanagan ME, Zaccard CR, Mesulam MM, Gefen T*, Geula C. Propagation of TDP-43 proteinopathy in neurodegenerative disorders. Neural Regen Res. 2022 Jul;17(7):1498-1500. doi: 10.4103/1673-5374.330609. PMID: 34916432; PMCID: PMC8771119.
BASAL FOREBRAIN CHOLINERGIC SYSTEM IN THE DEMENTIAS: VULNERABILITY, RESILIENCE, AND RESISTANCE
Geula C, Dunlop SR, Ayala I, Kawles AS*, Flanagan ME, Gefen T*, Mesulam MM. Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance. J Neurochem. 2021 Jul 17. doi: 10.1111/jnc.15471. Epub ahead of print. PMID: 34272732.
PAUCITY OF ENTORHINAL CORTEX PATHOLOGY OF THE ALZHEIMER’S TYPE IN SUPERAGERS WITH SUPERIOR MEMORY PERFORMANCE
Gefen T*, Kawles A*, Makowski-Woidan B, Engelmeyer J, Ayala I, Abbassian P, Zhang H, Weintraub S, Flanagan M, Mao Q, Bigio E, Rogalski E, Mesulam MM, Geula C. Paucity of Entorhinal Cortex Pathology of the Alzheimer’s Type in SuperAgers with Superior Memory Performance, Cerebral Cortex, 17 February 2021; bhaa409, https://doi.org/10.1093/cercor/bhaa409.
PRIMARY PROGRESSIVE APHASIA HAS A UNIQUE SIGNATURE DISTINCT FROM DEMENTIA OF THE ALZHEIMER'S TYPE AND BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA REGARDLESS OF PATHOLOGY
Gefen T*, Mao Q, Kohler M, Moeller S, Kawles A*, Coventry C, Spencer C, Lilek J, Ajroud K, Feldman A, Flanagan M, Rogalski E, Weintraub S, Rademaker A, Geula C, Mesulam MM, Bigio E. Primary Progressive Aphasia has a Unique Signature Distinct from Dementia of the Alzheimer's Type and Behavioral Variant Frontotemporal Dementia Regardless of Pathology. J Neuropathol Exp Neurol. 2020 Dec 4;79(12):1379-1381. doi: 10.1093/jnen/nlaa080. PMID: 33068393.
MONTREAL COGNITIVE ASSESSMENT (MOCA) PERFORMANCE AND DOMAIN-SPECIFIC INDEX SCORES IN AMNESTIC VERSUS APHASIC DEMENTIA
Wood JL, Weintraub S, Coventry C, Xu J, Zhang H, Rogalski E, Mesulam MM, Gefen T*. Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in Amnestic Versus Aphasic Dementia. J Int Neuropsychol Soc. 2020 Oct;26(9):927-931. doi: 10.1017/S135561772000048X. Epub 2020 May 19. PMID: 32423505; PMCID: PMC7554137.
MEASUREMENT AND CHARACTERIZATION OF DISTINCTIVE CLINICAL PHENOTYPES USING THE FRONTOTEMPORAL LOBAR DEGENERATION MODULE (FTLD-MOD)
Gefen T*, Teylan MA, Besser L, Pollner E, Moshkovich A, Weintraub S. Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD-MOD). Alzheimers Dement. 2020 Jun;16(6):918-925. doi: 10.1002/alz.12098. Epub 2020 May 13. PMID: 32400973; PMCID: PMC7580870.
ABSTRACTS & PRESENTATIONS
Distinct cognitive and neuropsychiatric features of amnestic dementia with comorbid Alzheimer and TDP-43 proteinopathies
Kochheiser M, Kawles A*, Minogue G*, Keszycki R*, Riley M, Mao Q, Flanagan M, Mesulam MM, Geula C, Weintraub S, and Gefen T*. Presented at the 2021 Alzheimer Association International Conference (AAIC), Denver CO, July 2021.
Clinicoanatomic Distribution of the 3R Tauopathy of Pick’s Disease in behavioral variant Frontotemporal Dementia (bvFTD)
Kawles, A.*, Kochheiser, M., Keszycki, R.*, Riley, M., Spencer, C., Lilek, J., Ayala, I., Shepard, R., Ajroud, K., Feldman, A., Mao, Q., Flanagan, M., Weintraub, S., Mesulam, M.-M., Bigio, E., Geula, C., and Gefen, T*. Presented (platform) at the 2021 International Neuropsychologist Society Conference (INS), San Diego CA, February 2021.
Neuropsychiatric phenotypes in PPA and bvFTD due to Pick’s disease
Keszycki, R.*, Kawles, A.*, Juthapan, S., Coventry, C., Zhang, H., Geula, C., Rogalski, E., Weintraub, S., Mesulam, M., and Gefen, T*. Presented at the 2021 International Neuropsychologist Society Conference (INS), San Diego CA, February 2021.
Integrity of Neuronal Size in the Entorhinal Cortex across the Cognitive Aging Spectrum
Nassif, C.*, Kawles, A.*, Minogue, G.*, Mao, Q., Flanagan, M., Bigio, E., Mesulam, M.-M., Rogalski, E., Geula, C., and Gefen, T*. Presented at the 2021 Society for Neuroscience Global Connectome Event (SfN), Virtual, January 2021.
Clinical features of limbic and subcortical Pick body distribution in behavioral variant Frontotemporal Dementia (bvFTD).
Kesyzcki, R.*, Kawles, A.*, Juthapan, S., Riley, M., Spencer, C., Lilek, J., Ayala, I., Shepard, R., Ajroud, K., Feldman, A., Mao, Q., Flanagan, M., Weintraub, S., Mesulam, M.-M., Bigio, E., Geula, C., and Gefen, T*. Presented at the 2021 Society for Neuroscience Global Connectome Event (SfN), Virtual, January 2021.
Putative Pathologic Correlates of Neurodegeneration in an Autopsy Series of FTLD-TDP Type C
Kawles, A.*, Nishihara, Y., Gill, N., Feldman, A., Zhang, H., Flanagan, M., Mesulam, M.-M., Geula, C., Bigio, E., Mao, Q., and Gefen, T*. Presented at the 2021 Society for Neuroscience Global Connectome Event (SfN), Virtual, January 2021.
Distinct Regional and Hemispheric Tau Distributions in Primary Progressive Aphasia with Neuropathologic Progressive Supranuclear Palsy: A Stereological Study
Zouridakis, A.*, Kawles, A.*, Minogue, G.*, Keszycki, R.*, Coventry, C., Weintraub, S., Rogalski, E., Flanagan, M. E., Mao, Q., Bigio, E., Mesulam, M.-M., Geula, C., Gefen, T*. To be presented at the 2022 Alzheimer’s Association International Conference (AAIC), San Diego, California, Hybrid, July 2022.
Hemispheric Vulnerability of 4R-type Progressive Supranuclear Palsy neuropathology in Primary Progressive Aphasia
Zouridakis, A.*, Kawles, A.*, Minogue, G.*, Keszycki, R.*, Rogalski, E., Mao, Q., Flanagan, M. E., Mesulam, M.-M., Geula, C., Gefen, T*. Presented at the Tau 2022 Global Conference, Virtual, February 2022.
Differential Vulnerability to the Dentate Gyrus to Tauopathies in Aphasic Dementia
Kawles, A.*, Minogue, G.*, Zouridakis, A.*, Nassif, C.*, Keszycki, R.*, Coventry, C., Rogalski, E., Flanagan, M., Mesulam, M.-M., Geula, C., Gefen, T*. Presented at the 2021 Society for Neuroscience (SfN) conference, Chicago, Illinois, Virtual, November 2021.
Concordance between Neocortical Distribution of Pick’s Disease and the Salience of Distinct Dementia Phenotypes
Kawles, A.*, Keszycki, R.*, Minogue, G.*, Zouridakis, A.*, Spencer, C., Ayala, I., Shepard, R., Gill, N., Lilek, J., Ajroud, K., Coventry, C., Rogalski, E., Weintraub, S., Feldman, A., Mao, Q., Flanagan, M., Zhang, H., Mesulam, M.-M., Geula, C., Gefen, T*. Presented at the 2021 Society for Neuroscience (SfN) conference, Chicago, Illinois, Virtual, November 2021.
Contributions of Tau and TDP-43 Hippocampal Pathology in Amnestic Dementia
Minogue, G.*, Kawles, A.*, Gill, N., Kochhesier, M., Keszycki, R.*, Lubbat, V., Ajroud, K., Spencer, C., Lilek, J., Flanagan, M., Zhang, H., Mesulam, M.-M., Geula, C., Gefen, T*. Presented at the 2021 Society for Neuroscience (SfN) conference, Chicago, Illinois, Virtual, November 2021.
Characterization of distinct neuropsychiatric trajectories in FTLD-tauopathies
Keszycki, R.*, Kawles, A.*, Minogue, G.*, Gill, N., Juthapan, S., Nassif, C.*, Riley, M., Coventry, C., Zhang, H., Rogalski, E., Weintraub, S., Mesulam, M.-M., Geula, C., Gefen, T*. Presented at the 2021 Society for Neuroscience (SfN) conference, Chicago, Illinois, Virtual, November 2021.